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Every 40 seconds an American dies from heart disease, stroke or other cardiovascular diseases, making it the #1 killer in America.  Heart disease and stroke take more lives than all forms of cancer combined and cost the US $314 billion a year in healthcare services and medications. But cardiovascular disease is not a number…it is our parents, husbands, wives and children.

The Hope was founded by renowned cardiovascular surgeon, Dr. Lester Sauvage who performed more than 10,000 surgeries in his career and mentored 40+ surgical fellows from around the world.

Dr. Mark Dedomenico joined Dr. Sauvage in 1965 and was the first cardiovascular fellow.  He worked with Dr. Sauvage until Dr. Sauvage passed away in 2015.  Although originally focused on treatment, Dr. Sauvage and Dr. Dedomenico were pioneers in understanding the need for research on the prevention of cardiovascular disease.  They were also the first people to explain the scientific link between cardiovascular disease and overweight/obesity, lack of exercise and other behaviors.  In the 1980’s, Dr. Dedomenico, with Dr. Sauvage’s support, began doing research on how to correct the growing epidemic of cardiovascular disease, most of which was caused by metabolic disorders, which included high cholesterol, high blood pressure, Type 2 Diabetes and many other related diseases.



As the Hope Heart institute finds new measures to prevent cardiovascular disease, The Hope will also continue to research methods to correct metabolic disorders without the use of drugs.  These include correcting or “curing” overweight/obesity, high cholesterol, hypertension, Pre-Type 2 Diabetes, Type 2 Diabetes, and other disorders that cause cardiovascular diseases.

Hope Research will examine causes of all metabolic disorders as they relate to altered behavior.  The focus will be on genetics and other tests that are related to:

  1. Nutrition
  2. Exercise
  3. Lifestyles
  4. Hormone Changes that cause aging of the body and the cardiovascular system
  5. Sleep Quality and Length and its relationship to weight gain
  6. Blood chemistries, Bio-markers and hormones.
  7. Metabolism relationship to body muscle and fat, VO2Max and the Basal Metabolic Rate
  8. Blood Sugar Response to different foods in different people
  9. Microbiomes in the Gastrointestinal Tract and their relationship to cardiovascular disease.


Dr. Dedomenico and The Hope have researched how stem cells repair the body.   Dr. Dedomenico spent the last 10 years successfully growing cartilage and tendons from stem cells, hoping that stem cell technology will eventually grow muscle.  And, as the science of stem cells advances, Dr. Dedomenico anticipates that stem cell research may also help stroke victims recover.

Dr. Dedomenico and The Hope are dedicated to being at the forefront of stem cell technology now and for years to come.